BDBM525773 US11174252, Compound 461

SMILES CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C(C)C)c4c3)cc2F)CC1

InChI Key InChIKey=NGYRNPFGDZALOR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525773   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525773BDBM525773(US11174252, Compound 461)
Affinity DataIC50: 3.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525773BDBM525773(US11174252, Compound 461)
Affinity DataIC50: 9nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525773BDBM525773(US11174252, Compound 461)
Affinity DataIC50: 17nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent