BDBM525798 US11174252, Compound 487

SMILES Fc1cnc(Nc2ccc(cn2)N2CCOCC2)nc1-c1cc(F)c2OCCN(C3CCC3)c2c1

InChI Key InChIKey=YQFQTKOIKKIREQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525798   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525798BDBM525798(US11174252, Compound 487)
Affinity DataIC50: 55nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525798BDBM525798(US11174252, Compound 487)
Affinity DataIC50: 112nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525798BDBM525798(US11174252, Compound 487)
Affinity DataIC50: 5.00E+3nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 525798BDBM525798(US11174252, Compound 487)
Affinity DataIC50: 5.00E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent