BDBM526649 (E)-1-(4-(dimethylamino)but-2-enoyl)-N-(3-(((8-isopropyl-2-((1-methylpiperidin- 4-yl)oxy)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)piperidine-3- carboxamide::US11186576, Compound 122.

SMILES CC(C)c1cnn2c(NCc3cccc(NC(=O)C4CCCN(C4)C(=O)\C=C\CN(C)C)c3)nc(OC3CCN(C)CC3)nc12

InChI Key InChIKey=IZTBLRSILOHFQO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526649   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM526649((E)-1-(4-(dimethylamino)but-2-enoyl)-N-(3-(((8-iso...)
Affinity DataIC50: 300nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent