BDBM526662 (1,4-cis)-4-(((E)-4-(dimethylamino)-4-oxobut-2-en-1-yl)amino)-N-(3-(((8- isopropyl-2-((1-methylpiperidin-4-yl)oxy)pyrazolo[1,5-a][1,3,5]triazin-4- yl)amino)methyl)phenyl)cyclohexane-1-carboxamide::US11186576, Compound 135.

SMILES CC(C)c1cnn2c(NCc3cccc(NC(=O)[C@@H]4CC[C@@H](CC4)NC\C=C\C(=O)N(C)C)c3)nc(OC3CCN(C)CC3)nc12

InChI Key InChIKey=VDLQREYGEVBDMV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526662   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM526662((1,4-cis)-4-(((E)-4-(dimethylamino)-4-oxobut-2-en-...)
Affinity DataIC50: 300nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent