BDBM527760 5-[1-(cyclopropylmethyl)-2- oxo-3-oxa-1,8- diazaspiro[4.5]dec-8-yl]-3-[1- (difluoromethyl)-1H-pyrazol- 4-yl]pyrazine-2-carbonitrile::US11179389, Compound 1-12

SMILES FC(F)n1cc(cn1)-c1nc(cnc1C#N)N1CCC2(COC(=O)N2CC2CC2)CC1

InChI Key InChIKey=BXXRGVMJHSTUBZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527760   

LigandPNGBDBM527760(5-[1-(cyclopropylmethyl)-2- oxo-3-oxa-1,8- diazasp...)
Affinity DataIC50: 54nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent