BDBM528347 9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethyl)-2-hydroxypyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 5
SMILES Oc1ccc2n(CC3CC3)c(=O)c3nnc(n3c2n1)C1(CC1)C1CC1
InChI Key InChIKey=XNUXIYGMZDJLFB-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 528347
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Human)
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 2.75nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 3nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Eli Lilly
US Patent
Eli Lilly
US Patent
Affinity DataIC50: 2.41nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair