BDBM528347 9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethyl)-2-hydroxypyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 5

SMILES Oc1ccc2n(CC3CC3)c(=O)c3nnc(n3c2n1)C1(CC1)C1CC1

InChI Key InChIKey=XNUXIYGMZDJLFB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 528347   

LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  2.75nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  3nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of human PDE6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  2.29E+4nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  2.00E+3nMAssay Description:The following phosphodiesterase activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  2.41nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent