BDBM530460 (S)-N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-(2-hydroxypropan-2-yl)-4-methyl-1H-pyrazol-1-yl)-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide::WO2022070069, Example 3

SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1cc(C)c(n1)C(C)(C)O)C(F)(F)F

InChI Key InChIKey=OIFBFTGIRJTPFV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 530460   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM530460(WO2022070069, Example 3 | (S)-N-(2-Chloro-6-fluoro...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human DHODH using DHO and CoQ6 as substrate by DCIP dye based spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM530460(WO2022070069, Example 3 | (S)-N-(2-Chloro-6-fluoro...)
Affinity DataIC50: 0.5nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
WIPO WO2022070069