BDBM530894 (R)-N1-(3-amino-2- hydroxypropyl)-4-(3- oxo-2-oxa-4,9- diazaspiro[5.5]undecan- 9-yl)-3-(2H-tetrazol-5- yl)benzene-1,2- disulfonamide::US11207312, Example 26

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC3(CC2)CNC(=O)OC3)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=BYIRAZZBHXLXQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 530894   

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530894(US11207312, Example 26 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.630nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530894(US11207312, Example 26 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 0.640nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530894(US11207312, Example 26 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 1.02nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530894(US11207312, Example 26 | (R)-N1-(3-amino-2- hydrox...)
Affinity DataIC50: 2.74nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent