BDBM531221 2-(6-(((cis)-3-Hydroxy-3-methylcyclobutyl)amino)pyridazin-3-yl)-3-methyl-5-(trifluoromethyl)phenol::US11208399, Example 2

SMILES Cc1cc(cc(O)c1-c1ccc(N[C@H]2C[C@@](C)(O)C2)nn1)C(F)(F)F

InChI Key InChIKey=ZIKFUBFPICKFQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531221   

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandPNGBDBM531221(US11208399, Example 2 | 2-(6-(((cis)-3-Hydroxy-3-m...)
Affinity DataIC50: 10.2nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Novartis

US Patent
LigandPNGBDBM531221(US11208399, Example 2 | 2-(6-(((cis)-3-Hydroxy-3-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent