BDBM531222 2-(6-(((1R,3S)-3-Hydroxycyclohexyl)amino)pyridazin-3-yl)-3-methyl-5-(trifluoromethyl)phenol::US11208399, Example 3

SMILES Cc1cc(cc(O)c1-c1ccc(N[C@@H]2CCC[C@H](O)C2)nn1)C(F)(F)F

InChI Key InChIKey=QUUIPPFTSZOOFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531222   

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandPNGBDBM531222(US11208399, Example 3 | 2-(6-(((1R,3S)-3-Hydroxycy...)
Affinity DataIC50: 25.5nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Novartis

US Patent
LigandPNGBDBM531222(US11208399, Example 3 | 2-(6-(((1R,3S)-3-Hydroxycy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent