BDBM531313 US11208399, Example 67

SMILES Cc1cc(cc(O)c1-c1ccc(N[C@H]2C[C@@](O)(C2)C(F)(F)F)nn1)C(F)(F)F

InChI Key InChIKey=DHPFQKDDYKRIHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531313   

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandPNGBDBM531313(US11208399, Example 67)
Affinity DataIC50: 40.1nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Novartis

US Patent
LigandPNGBDBM531313(US11208399, Example 67)
Affinity DataIC50: 4.60E+4nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent