BDBM534163 6-Cyclopropyl-4-fluoro-N-(2-phenylphenyl)sulfonyl-benzofuran-2-carboxamide::WO2022081842, Example 38

SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1

InChI Key InChIKey=XXKOKQRJJNVVBF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 534163   

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandChemical structure of BindingDB Monomer ID 534163BDBM534163(WO2022081842, Example 38 | 6-Cyclopropyl-4-fluoro-...)
Affinity DataIC50: 17nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534163BDBM534163(WO2022081842, Example 38 | 6-Cyclopropyl-4-fluoro-...)
Affinity DataIC50: 173nMAssay Description:Inhibition of his-tagged human recombinant KAT6A (194 to 810 residues) expressed in baculovirus-infected Sf9 insect cells using H4-derived peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone acetyltransferase KAT6A(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534163BDBM534163(WO2022081842, Example 38 | 6-Cyclopropyl-4-fluoro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KAT6A in human MVLN cells assessed as decrease in estrogen receptor level incubated for 24 hrs by gene reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed