BDBM534181 N-{[1,1'-Biphenyl]-2-sulfonyl}-6-(propan-2-yl)-1-benzofuran-2-carboxamide::WO2022081842, Example 54

SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1

InChI Key InChIKey=ZRIUOJCZGYZBQA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 534181   

TargetHistone acetyltransferase KAT6A(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534181BDBM534181(WO2022081842, Example 54 | N-{[1,1'-Biphenyl]-2-su...)
Affinity DataIC50: 464nMAssay Description:Inhibition of his-tagged human recombinant KAT6A (194 to 810 residues) expressed in baculovirus-infected Sf9 insect cells using H4-derived peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandChemical structure of BindingDB Monomer ID 534181BDBM534181(WO2022081842, Example 54 | N-{[1,1'-Biphenyl]-2-su...)
Affinity DataIC50: 464nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6B(Human)
The Broad Institute

WIPO
LigandChemical structure of BindingDB Monomer ID 534181BDBM534181(WO2022081842, Example 54 | N-{[1,1'-Biphenyl]-2-su...)
Affinity DataIC50: 667nMAssay Description: Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534181BDBM534181(WO2022081842, Example 54 | N-{[1,1'-Biphenyl]-2-su...)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of KAT6A in human MVLN cells assessed as decrease in estrogen receptor level incubated for 24 hrs by gene reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed