BDBM534634 US11229631, Example 18 Diastereoisomer 2

SMILES N[C@H]1CCCN(C1)c1c2CCC(C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F

InChI Key InChIKey=QLLAOUOYSHXDOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 534634   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM534634(US11229631, Example 18 Diastereoisomer 2)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM534634(US11229631, Example 18 Diastereoisomer 2)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM534634(US11229631, Example 18 Diastereoisomer 2)
Affinity DataIC50: 550nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent