BDBM535952 US11242337, Example 58

SMILES CC(C)(C)OC(=O)N[C@@H]1CCCN(C1)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCCCn1cc(CNC(=O)NCCCCNC(=O)NCc2cn(CCCCNS(=O)(=O)c3ccc(O[C@@H]4[C@H](Cc5c4cc(Cl)cc5Cl)N4CCC[C@H](C4)NC(=O)OC(C)(C)C)cc3)nn2)nn1

InChI Key InChIKey=DFZUCGYRSOAQBP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535952   

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM535952(US11242337, Example 58)
Affinity DataIC50: 100nMAssay Description:The ability of compounds to inhibit human and rat NHE-3-mediated Na+ dependent H+ antiport after application and washout was measured using a modific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM535952(US11242337, Example 58)
Affinity DataIC50: 100nMAssay Description:Rat and human NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Paradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent