BDBM536038 US11242337, Example 154

SMILES Clc1cc2[C@H](Oc3ccc(cc3)S(=O)(=O)NC3CCN(CC3)C(=O)CCCNC(=O)NCCCC(=O)N3CCC(CC3)NS(=O)(=O)c3ccc(O[C@@H]4[C@H](Cc5c4cc(Cl)cc5C#N)N4CCNCC4)cc3)[C@H](Cc2c(c1)C#N)N1CCNCC1

InChI Key InChIKey=GYXKTMARXCFQOM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536038   

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM536038(US11242337, Example 154)
Affinity DataIC50: 100nMAssay Description:Rat and human NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Paradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM536038(US11242337, Example 154)
Affinity DataIC50: 100nMAssay Description:The ability of compounds to inhibit human and rat NHE-3-mediated Na+ dependent H+ antiport after application and washout was measured using a modific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent