BDBM536291 (5S)-2-((4R)-1-(2-(3-((6-(2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethoxy)hexa-2,4-diyn-1-yl)oxy)isoxazol-5-yl)-3-methylbutanoyl)-4-hydroxypyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-1,5-dihydro-4H-imidazol-4-one ::US11242344, Example 1004.1
SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOCC#CC#CCOc1cc(on1)[C@@H](C(C)C)C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C
InChI Key InChIKey=GDUPOTCODJXPBK-FZCWASTKSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 536291
Affinity DataIC50: 6.83E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213](Homo sapiens (Human))
Genentech
US Patent
Genentech
US Patent
Affinity DataIC50: 6.25E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair