BDBM537310 N-methyl-3-(1-methyl-1H- pyrazol-4-yl)-1-((1s,4s)-4-((2- methylpyridin-3- yl)oxy)cyclohexyl)-1H- pyrazolo[4,3-c]pyridin-6-amine::US11247990, Example 135

SMILES CNc1cc2c(cn1)c(-c1cnn(C)c1)nn2C1CCC(Oc2cccnc2C)CC1

InChI Key InChIKey=FMDIRUAQORTXAX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 537310   

TargetTyrosine-protein kinase Mer(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 537310BDBM537310(US11247990, Example 135 | N-methyl-3-(1-methyl-1H-...)
Affinity DataIC50: 20nMAssay Description:MER: Compounds of Formula I were screened for their ability to inhibit MER kinase using Invitrogen's LanthaScreen Eu Kinase Binding technology. H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 537310BDBM537310(US11247990, Example 135 | N-methyl-3-(1-methyl-1H-...)
Affinity DataIC50: 20nMAssay Description:AXL: Compounds of Formula I were screened for their ability to inhibit AXL kinase using Invitrogen's LanthaScreen Eu Kinase Binding technology. H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 537310BDBM537310(US11247990, Example 135 | N-methyl-3-(1-methyl-1H-...)
Affinity DataIC50: 110nMAssay Description:TYRO3: Compounds of Formula I were screened for their ability to inhibit TYRO3 kinase using Invitrogen's LanthaScreen Eu Kinase Binding technolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent