BDBM538065 4-(4-fluoro-3-(1-(3- fluoropyridin-2-yl)-4-oxido- 1,4-azaphosphinan-4- yl)benzyl)phthalazin-1(2H)- one::US11248013, Example 23

SMILES O=c1[nH]nc(Cc2ccc(F)c(P3(=O)CCN(c4ncccc4F)CC3)c2)c2ccccc12

InChI Key InChIKey=QIERHUUXAJEAIY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 538065   

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 538065BDBM538065(4-(4-fluoro-3-(1-(3- fluoropyridin-2-yl)-4-oxido- ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
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Date in BDB:
6/13/2022
Entry Details
US Patent