BDBM538076 4-(4-fluoro-3-(4-oxido-1-(5- (n-propyl)pyrimidin-2-yl)- 1,4-azaphosphinan-4- yl)benzyl)phthalazin-1(2H)- one::US11248013, Example 37

SMILES CCCc1cnc(N2CCP(=O)(c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)nc1

InChI Key InChIKey=IXFDPFHDABHEOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 538076   

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 538076BDBM538076(4-(4-fluoro-3-(4-oxido-1-(5- (n-propyl)pyrimidin-2...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
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Date in BDB:
6/13/2022
Entry Details
US Patent