BDBM538082 4-(3-(1- (cyclopropylmethyl)-4- oxido-1,4-azaphosphinan- 4-yl)-4-fluorobenzyl)phthalazin-1(2H)-one::US11248013, Example 43

SMILES O=c1[nH]nc(Cc2ccc(F)c(P3(=O)CCN(CC4CC4)CC3)c2)c2ccccc12

InChI Key InChIKey=ZXKVRUWVABXLQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 538082   

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 538082BDBM538082(4-(3-(1- (cyclopropylmethyl)-4- oxido-1,4-azaphosp...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent