BDBM538640 NCGC 00249356::US11254667, Compound I-45::US11542261, Compound I-45

SMILES C1NCC1Nc1cccc(n1)-c1cnc2ccc(cn12)-c1cn[nH]c1

InChI Key InChIKey=HCMGPAIQYFWRHN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 538640   

TargetGTPase NRas(Homo sapiens (Human))
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  4.29E+3nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  460nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  4.29E+3nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  460nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent