BDBM539194 4-(3-((R)-3-aminopiperidine-1-carbonyl)- 1-(2-fluoro-4-(3-methoxypyrrolidin-1-yl) phenyl)-1H-pyrazol-5-yl)-2-fluorobenzo- nitrile::US11254676, Example 65

SMILES COC1CCN(C1)c1ccc(c(F)c1)-n1nc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CCC[C@@H](N)C1

InChI Key InChIKey=BQXRMZGIIUTZCL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539194   

TargetLysine-specific histone demethylase 1A(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM539194(4-(3-((R)-3-aminopiperidine-1-carbonyl)- 1-(2-fluo...)
Affinity DataIC50: 53nMAssay Description:The biochemical inhibition activity of the synthesized compounds on LSD1 was measured. The activity measurement was performed using LSD1 fluorescence...More data for this Ligand-Target Pair
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Date in BDB:
6/19/2022
Entry Details
US Patent