BDBM539863 (E)-2-(4-(3-(benzo [b] thien-2-yl)-3-oxo-1-propen-1-yl)-2,6-dimethylphenoxy)-2-methylpropionic acid (TM1)::US11261170, Example 2

SMILES Cc1cc(\C=C\C(=O)c2cc3ccccc3s2)cc(C)c1OC(C)(C)C(O)=O

InChI Key InChIKey=ZAJBALGZMIMWGY-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 539863   

TargetPeroxisome proliferator-activated receptor alpha(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM539863((E)-2-(4-(3-(benzo [b] thien-2-yl)-3-oxo-1-propen-...)
Affinity DataEC50:  1.21E+3nMAssay Description:HEK293 cells were incubated in DMEM medium containing 10% of fetal bovine serum at 37° C. in the presence of 5% of CO2. 3×105/ml cells were plated in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetPeroxisome proliferator-activated receptor delta(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM539863((E)-2-(4-(3-(benzo [b] thien-2-yl)-3-oxo-1-propen-...)
Affinity DataEC50:  6.13E+3nMAssay Description:HEK293 cells were incubated in DMEM medium containing 10% of fetal bovine serum at 37° C. in the presence of 5% of CO2. 3×105/ml cells were plated in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM539863((E)-2-(4-(3-(benzo [b] thien-2-yl)-3-oxo-1-propen-...)
Affinity DataIC50: 8.24E+3nMAssay Description:The effect of the compound on hERG potassium ion channel was tested by Predictor hERG fluorescence polarization. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent