BDBM540280 (R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-32

SMILES C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21

InChI Key InChIKey=FATCNTFSENHZBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540280   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540280BDBM540280((R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540280BDBM540280((R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent