BDBM540283 (4R,7R,E)-5'-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-35

SMILES C[C@@H]1Cc2cc(ncn2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1

InChI Key InChIKey=ITZDIEFBIHYMSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540283   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540283BDBM540283((4R,7R,E)-5'-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540283BDBM540283((4R,7R,E)-5'-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent