BDBM540290 (33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-pyrrolidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-42

SMILES C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CC[C@@H](C2)Oc2ccc(F)cc21

InChI Key InChIKey=DOOASRFGZIHKNC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540290   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540290BDBM540290((33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-i...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540290BDBM540290((33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-i...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent