BDBM540302 (32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-54

SMILES Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2

InChI Key InChIKey=MLQXYJATWUNBGZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540302   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540302BDBM540302((32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540302BDBM540302((32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent