BDBM540307 (14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-59

SMILES Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2

InChI Key InChIKey=PXUOTBWWSVWXDX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540307   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540307BDBM540307((14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540307BDBM540307((14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent