BDBM540311 (14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-etheno imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-63

SMILES Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2

InChI Key InChIKey=UNUMGPSAYSQYBE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540311   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540311BDBM540311((14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540311BDBM540311((14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent