BDBM540314 (14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-66

SMILES Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2

InChI Key InChIKey=DFIOTNNBLLFSRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540314   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540314BDBM540314((14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydr...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540314BDBM540314((14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydr...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent