BDBM540386 (3S)-3-((5aR)-7-((2-(4-((1S, 2R)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen- 1-yl)phenyl)-5-oxa-2-azaspiro [3.4]octan-7-yl)methyl)-1-oxo- 1,3,5,5a,6,7,8,9-octahydro-2H- pyrazino[1',2':4,5][1,4]oxazino [2,3-e]isoindol-2-yl)piperidine- 2,6-dione::US20260028354, Compound A41

SMILES O=C1CC[C@H](N2Cc3c(ccc4c3OC[C@H]3CN(CC5COC6(C5)CN(c5ccc([C@H]7c8ccc(O)cc8CC[C@H]7c7ccccc7)cc5)C6)CCN43)C2=O)C(=O)N1

InChI Key InChIKey=KSFCBLBRCLIOOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540386   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540386BDBM540386((3S)-3-((5aR)-7-((2-(4-((1S, 2R)-6-hydroxy-2-pheny...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540386BDBM540386((3S)-3-((5aR)-7-((2-(4-((1S, 2R)-6-hydroxy-2-pheny...)
Affinity DataIC50: 50nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent