BDBM540397 (3S)-3-((5aRS)-7-((8-(4-((1R, 2R)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen- 1-yl)-3-methoxyphenyl)-1- oxa-8-azaspiro[4.5]decan-3- yl)methyl)-1-oxo-1,3,5,5a,6,7, 8,9-octahydro-2H-pyrazino [1',2':4,5][1,4]oxazino[2,3-e] isoindol-2-yl)piperidine-2,6- dione::US20260028354, Compound A52

SMILES COc1cc(N2CCC3(CC2)CC(CN2CCN4c5ccc6c(c5OC[C@H]4C2)CN([C@H]2CCC(=O)NC2=O)C6=O)CO3)ccc1[C@H]1c2ccc(O)cc2CC[C@H]1c1ccccc1

InChI Key InChIKey=XTCPVWMEHQILFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540397   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540397BDBM540397((3S)-3-((5aRS)-7-((8-(4-((1R, 2R)-6-hydroxy-2-phen...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540397BDBM540397((3S)-3-((5aRS)-7-((8-(4-((1R, 2R)-6-hydroxy-2-phen...)
Affinity DataIC50: 50nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent