BDBM540399 (3S)-3-(1'-((8-(4-((1R,2R)-6- hydroxy-2-phenyl-1,2,3,4- tetrahydronaphthalen-1-yl)-3- methoxyphenyl)-1-oxa-8-aza- spiro[4.5]decan-3-yl)methyl)- 6-oxo-6,8-dihydro-2H,7H- spiro[furo[2,3-e]isoindole-3,4'- piperidin]-7-yl)piperidine-2,6- dione::US20260028354, Compound A54

SMILES COc1cc(N2CCC3(CC2)CC(CN2CCC4(CC2)COc2c4ccc4c2CN([C@H]2CCC(=O)NC2=O)C4=O)CO3)ccc1[C@H]1c2ccc(O)cc2CC[C@H]1c1ccccc1

InChI Key InChIKey=MOLMKMIVOQUOCP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540399   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540399BDBM540399((3S)-3-(1'-((8-(4-((1R,2R)-6- hydroxy-2-phenyl-1,2...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540399BDBM540399((3S)-3-(1'-((8-(4-((1R,2R)-6- hydroxy-2-phenyl-1,2...)
Affinity DataIC50: 50nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent