BDBM540415 (S)-3-((R)-7-(((R)-2-(4- ((1R,2S)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen-1- yl)phenyl)-5-oxa-2- azaspiro[3.4]octan-7-yl)methyl)- 1-oxo-1,3,5,5a,6,7,8,9- octahydro-2H- pyrazino[1',2':4,5][1,4] oxazino[2,3- e]isoindol-2-yl)piperidine-2,6- dione::US20260028354, Compound A69

SMILES O=C1CC[C@H](N2Cc3c(ccc4c3OC[C@H]3CN(C[C@@H]5COC6(C5)CN(c5ccc([C@@H]7c8ccc(O)cc8CC[C@@H]7c7ccccc7)cc5)C6)CCN43)C2=O)C(=O)N1

InChI Key InChIKey=KSFCBLBRCLIOOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540415   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540415BDBM540415((S)-3-((R)-7-(((R)-2-(4- ((1R,2S)-6-hydroxy-2-phen...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540415BDBM540415((S)-3-((R)-7-(((R)-2-(4- ((1R,2S)-6-hydroxy-2-phen...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent