BDBM540417 (S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1,2,3,4-tetra- hydronaphthalen-1-yl)phenyl)- piperidin-4-yl)methyl)-1-oxo- 1,3,5,5a,6,7,8,9-octahydro-2H- pyrazino[1',2':4,5][1,4]oxazino [2,3-e]isoindol-2-yl)piperidine- 2,6-dione::US20260028354, Compound A71

SMILES O=C1CC[C@H](N2Cc3c(ccc4c3OC[C@H]3CN(CC5CCN(c6ccc([C@@H]7c8ccc(O)cc8CC[C@@H]7c7ccccc7)cc6)CC5)CCN43)C2=O)C(=O)N1

InChI Key InChIKey=UKLWSSWMABLANO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540417   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540417BDBM540417((S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540417BDBM540417((S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent