BDBM540418 (S)-3-((S)-3-(((S)-2-(4-((1R, 2S)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen- 1-yl)phenyl)-5-oxa-2-azaspiro [3.4]octan-7-yl)methyl)-8-oxo- 1,2,3,4,4a,5,8,10-octahydro- 9H-pyrazino[1',2':4,5][1,4] oxazino[2,3-f]isoindol-9-yl)- piperidine-2,6-dione::US20260028354, Compound A72

SMILES O=C1CC[C@H](N2Cc3cc4c(cc3C2=O)OC[C@@H]2CN(C[C@H]3COC5(C3)CN(c3ccc([C@@H]6c7ccc(O)cc7CC[C@@H]6c6ccccc6)cc3)C5)CCN42)C(=O)N1

InChI Key InChIKey=CNEDTGZOLSMSSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540418   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540418BDBM540418((S)-3-((S)-3-(((S)-2-(4-((1R, 2S)-6-hydroxy-2-phen...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540418BDBM540418((S)-3-((S)-3-(((S)-2-(4-((1R, 2S)-6-hydroxy-2-phen...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent