BDBM540422 (S)-3-(1'-(((S)-2-(4-((1R,2S)-6- hydroxy-2-phenyl-1,2,3,4- tetrahydronaphthalen-1- yl)phenyl)-5-oxa-2- azaspiro[3.4]octan-7-yl)methyl)- 7-oxo-5,7-dihydro-2H,6H- spiro[furo[2,3-f]isoindole-3,4'- piperidin]-6-yl)piperidine-2,6- dione::US20260028354, Compound A76

SMILES O=C1CC[C@H](N2Cc3cc4c(cc3C2=O)OCC42CCN(C[C@H]3COC4(C3)CN(c3ccc([C@@H]5c6ccc(O)cc6CC[C@@H]5c5ccccc5)cc3)C4)CC2)C(=O)N1

InChI Key InChIKey=SRMPQCXYJGZRMJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540422   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540422BDBM540422((S)-3-(1'-(((S)-2-(4-((1R,2S)-6- hydroxy-2-phenyl-...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540422BDBM540422((S)-3-(1'-(((S)-2-(4-((1R,2S)-6- hydroxy-2-phenyl-...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent