BDBM540428 (S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1,2,3,4- tetrahydronaphthalen-1-yl)- phenyl)-4-methoxypiperidin-4- yl)methyl)-1-oxo-1,3,5,5a,6,7, 8,9-octahydro-2H-pyrazino [1',2':4,5][1,4]oxazino[2,3-c] isoindol-2-yl)piperidine-2,6- dione::US20260028354, Compound A82

SMILES COC1(CN2CCN3c4ccc5c(c4OC[C@H]3C2)CN([C@H]2CCC(=O)NC2=O)C5=O)CCN(c2ccc([C@@H]3c4ccc(O)cc4CC[C@@H]3c3ccccc3)cc2)CC1

InChI Key InChIKey=FNOFFFQDYGIPGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540428   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540428BDBM540428((S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540428BDBM540428((S)-3-((R)-7-((1-(4-((1R,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent