BDBM540437 (S)-3-((S)-3-((1-(2-fluoro-4- ((1S,2S)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen-1- yl)-5-methoxyphenyl)piperidin- 4-yl)methyl)-8-oxo- 1,2,3,4,4a,5,8,10-octahydro-9H- pyrazino[1',2':4,5][1,4] oxazino[2,3- f]isoindol-9-yl)piperidine-2,6- dione::US20260028354, Compound A91

SMILES COc7cc(N6CCC(CN5CCN4c3cc2CN([C@H]1CCC(=O)NC1=O)C(=O)c2cc3OC[C@@H]4C5)CC6)c(F)cc7[C@@H]9c8ccc(O)cc8CC[C@@H]9c%10ccccc%10

InChI Key InChIKey=FHNHVKMDGYYSCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540437   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
Regent Of The University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 540437BDBM540437((S)-3-((S)-3-((1-(2-fluoro-4- ((1S,2S)-6-hydroxy-2...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
Regent Of The University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 540437BDBM540437((S)-3-((S)-3-((1-(2-fluoro-4- ((1S,2S)-6-hydroxy-2...)
Affinity DataIC50: 2.75E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent