BDBM540447 (S)-3-((S)-3-((7-(2-fluoro-4- ((1S,2S)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen- 1-yl)-5-methoxyphenyl)-7-aza- spiro[3.5]nonan-2-yl)methyl)- 8-oxo-1,2,3,4,4a,5,8,10-octa- hydro-9H-pyrazino[1',2':4,5] [1,4]oxazino[2,3-f]isoindol-9- yl)piperidine-2,6-dione::US20260028354, Compound A101

SMILES COc1cc(N2CCC3(CC2)CC(CN2CCN4c5cc6c(cc5OC[C@@H]4C2)C(=O)N([C@H]2CCC(=O)NC2=O)C6)C3)c(F)cc1[C@@H]1c2ccc(O)cc2CC[C@@H]1c1ccccc1

InChI Key InChIKey=BWNRWYVBCNDBDY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540447   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540447BDBM540447((S)-3-((S)-3-((7-(2-fluoro-4- ((1S,2S)-6-hydroxy-2...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540447BDBM540447((S)-3-((S)-3-((7-(2-fluoro-4- ((1S,2S)-6-hydroxy-2...)
Affinity DataIC50: 5.00E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent