BDBM540448 (S)-3-((R)-7-((7-(5-fluoro-4- ((1R,2R)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen- 1-yl)-2-methoxyphenyl)-7-aza- spiro[3.5]nonan-2-yl)methyl)- 1-oxo-1,3,5,5a,6,7,8,9-octa- hydro-2H-pyrazino[1',2':4,5] [1,4]oxazino[2,3-e]isoindol-2- yl)piperidine-2,6-dione::US20260028354, Compound A102

SMILES COc1cc([C@H]2c3ccc(O)cc3CC[C@H]2c2ccccc2)c(F)cc1N1CCC2(CC1)CC(CN1CCN3c4ccc5c(c4OC[C@H]3C1)CN([C@H]1CCC(=O)NC1=O)C5=O)C2

InChI Key InChIKey=YYYWLDIZFQAEKZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 540448   

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540448BDBM540448((S)-3-((R)-7-((7-(5-fluoro-4- ((1R,2R)-6-hydroxy-2...)
Affinity DataIC50: 50nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent