BDBM540458 (S)-3-((R)-7-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1,2,3,4- tetrahydronaphthalen-1- yl)pyridin-2-yl)-7- azaspiro[3.5]nonan-2- yl)methyl)-1-oxo- 1,3,5,5a,6,7,8,9-octahydro-2H- pyrazino[1',2':4,5][1,4] oxazino[2,3- e]isoindol-2-yl)piperidine-2,6- dione::US20260028354, Compound A112

SMILES O=C1CC[C@H](N2Cc3c(ccc4c3OC[C@H]3CN(CC5CC6(CCN(c7ccc([C@@H]8c9ccc(O)cc9CC[C@@H]8c8ccccc8)cn7)CC6)C5)CCN43)C2=O)C(=O)N1

InChI Key InChIKey=SUJHDLOXSQHJOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540458   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
Regent Of The University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 540458BDBM540458((S)-3-((R)-7-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
Regent Of The University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 540458BDBM540458((S)-3-((R)-7-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1...)
Affinity DataIC50: 275nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent