BDBM540460 (S)-3-(1'-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1,2,3,4-tetra- hydronaphthalen-1-yl)pyridin- 2-yl)-7-azaspiro[3.5]nonan-2- yl)methyl)-6-oxo-6,8-dihydro- 2H,7H-spiro[furo[2,3-e]iso- indole-3,4'-piperidin]-7-yl)- piperidine-2,6-dione::US20260028354, Compound A116

SMILES O=C1CC[C@H](N2Cc3c(ccc4c3OCC43CCN(CC4CC5(CCN(c6ccc([C@@H]7c8ccc(O)cc8CC[C@@H]7c7ccccc7)cn6)CC5)C4)CC3)C2=O)C(=O)N1

InChI Key InChIKey=ADWKQGRMSXWCOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540460   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540460BDBM540460((S)-3-(1'-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1,2,...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 540460BDBM540460((S)-3-(1'-((7-(5-((1S,2S)-6- hydroxy-2-phenyl-1,2,...)
Affinity DataIC50: 50nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent