BDBM540512 (S)-3-(1'-(((R)-8-(2-fluoro-4- ((1S,2S)-6-hydroxy-2-phenyl- 1,2,3,4-tetrahydronaphthalen-1- yl)-5-methoxyphenyl)-1-oxa-8- azaspiro[4.5]decan-3-yl)methyl)- 7-oxo-5,7-dihydro-2H,6H- spiro[furo[2,3-f]isoindole-3,4'- piperidin]-6-yl)piperidine-2,6- dione::US20260028354, Compound A175

SMILES COc1cc(N2CCC3(CC[C@@H](CN4CCC5(CC4)COc4cc6c(cc45)CN([C@H]4CCC(=O)NC4=O)C6=O)O3)CC2)c(F)cc1[C@@H]1c2ccc(O)cc2CC[C@@H]1c1ccccc1

InChI Key InChIKey=MJDSLQUHBVPRAB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 540512   

TargetEstrogen receptor [282-595](Homo sapiens (Human))
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US Patent
LigandChemical structure of BindingDB Monomer ID 540512BDBM540512((S)-3-(1'-(((R)-8-(2-fluoro-4- ((1S,2S)-6-hydroxy-...)
Affinity DataIC50: 10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent