BDBM541415 US11267811, Example 2

SMILES OC[C@H]1O[C@H]([C@H](O)[C@H]([C@H]1O)n1cc(nn1)-c1cc(F)c(F)c(F)c1)n1nncc1-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=XHTKEWSTFBVAFG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 541415   

TargetGalectin-3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541415(US11267811, Example 2)
Affinity DataIC50: 256nMAssay Description:Inhibition of His-tagged recombinant human Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGalectin-3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541415(US11267811, Example 2)
Affinity DataIC50: 260nMAssay Description:The Gal-3 assays were performed in 384 white Opti plates in three replicates at room temperature with gentle shaking at 250-300 rpmFrom the original ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
US Patent

TargetGalectin-3(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541415(US11267811, Example 2)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of His-tagged recombinant mouse Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed