BDBM541466 US11267811, Example 60

SMILES Cc1nc([C@@H]2O[C@H](CO)[C@H](O)[C@@H]([C@H]2O)n2cc(nn2)-c2cc(F)c(F)c(F)c2)n(n1)-c1cc(Cl)ccc1F

InChI Key InChIKey=DQFXWKVASMNKLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 541466   

TargetGalectin-3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541466(US11267811, Example 60)
Affinity DataIC50: 65nMAssay Description:Inhibition of His-tagged recombinant human Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGalectin-3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541466(US11267811, Example 60)
Affinity DataIC50: 70nMAssay Description:The Gal-3 assays were performed in 384 white Opti plates in three replicates at room temperature with gentle shaking at 250-300 rpmFrom the original ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
US Patent

TargetGalectin-3(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM541466(US11267811, Example 60)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of His-tagged recombinant mouse Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed