BDBM542598 (1S,3′R,6′R,7′S,8′E,16′R)-6-CHLORO-7′,16′-DIHYDROXY-13′-METHYL-N-(METHYLSULFONYL)-14′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,23′-[21]OXA[1,13]DIAZATETRACYCLO[15.7.2.03,6.020,25]HEXACOSA[8,17,19,25]TETRAENE]-16′-CARBOXAMIDE::US11274105, Example 88

SMILES CN1CCC\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@@](O)(CC1=O)C(=O)NS(C)(=O)=O

InChI Key InChIKey=SLBHPGSGHVUBSH-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 542598   

LigandPNGBDBM542598((1S,3′R,6′R,7′S,8′E,16R...)
Affinity DataIC50: 0.240nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/5/2022
Entry Details
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LigandPNGBDBM542598((1S,3′R,6′R,7′S,8′E,16R...)
Affinity DataIC50: 3.28nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
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LigandPNGBDBM542598((1S,3′R,6′R,7′S,8′E,16R...)
Affinity DataKi:  0.0930nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent