BDBM542674 (1S,3′R,6′R,7′S,8′E,15′R)-6-CHLORO-15′-HYDROXY-12′-METHYL-7′-(2-(4-MORPHOLINYL)ETHOXY)-13′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12]DIAZATETRACYCLO[14.7.2.03,6.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXYLIC ACID::US11274105, Example 173

SMILES CN1CC\C=C\[C@H](OCCN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(O)=O

InChI Key InChIKey=SYOLDYOINCAAKM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 542674   

LigandPNGBDBM542674((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50: 0.490nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/5/2022
Entry Details
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LigandPNGBDBM542674((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataIC50: 2.48nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
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LigandPNGBDBM542674((1S,3′R,6′R,7′S,8′E,15R...)
Affinity DataKi:  0.0860nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
Go to US Patent