BDBM543492 US11279703, TABLE 3.1::US11279703, TABLE 3.4::US11279703, TABLE 5.2::US11279703, TABLE 6.201::US11279703, TABLE 6.220::US11279703, TABLE 6.279

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4cccc(NS(=O)(=O)C5CC5)c4)c3n2)cc1

InChI Key InChIKey=YTKRLXPJRGPIKN-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 543492   

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 2.5nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 2.5nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 2.5nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 4.30nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 4.30nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 8nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 31nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 69nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 244nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 355nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 355nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 729nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 825nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 1.35E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 1.46E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 1.74E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 1.80E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 1.90E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein [22-138](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 2.50E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein [22-138](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 2.63E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543492(US11279703, TABLE 3.1 | US11279703, TABLE 6.220 | ...)
Affinity DataIC50: 6.21E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent